Harnessing Structural Insights Into Bacterial Zinc Efflux for New Therapeutics

Distinct structural features of Pseudomonas aeruginosa ATP synthase revealed by cryo-electron microscopy

M Sobti, AP Gunn, SHJ Brown, L Zavan, VM Fraunfelter, AL Wolfe, CA McDevitt, PR Steed, AG Stewart

2026-12-01

F<inf>1</inf>F<inf>o</inf> ATP synthase is the ubiquitous enzyme that synthesizes cellular ATP by coupling proton-motive force wit..

PBT2 potentiates carbapenem antibiotics against diverse Klebsiella pneumoniae strains.

Aimee Tan, Abigail R Hartono, Adam P Gunn, Claire L Gorrie, David MP De Oliveira, Francesca L Short, Mark J Walker, Norelle L Sherry, Benjamin P Howden, Christopher A McDevitt

2026-09-25

UNLABELLED: Carbapenem-resistant Klebsiella pneumoniae is recognized by the World Health Organization as a critical priority for u..